Revolutionizing medicine: Molecularly imprinted polymers as precision tools in cancer diagnosis and antibiotic detection

Molecularly imprinted polymers for medical diagnosis


  • Sargol Aminnezhad Department of Microbiology, Faculty of Biological Sciences, Alzahra University, Tehran, Iran
  • Qassim Hassan Aubais Aljelehawy Department of Chemistry, College of Education, University of Alqadisiya, Iraq
  • Mohammad Rezaei Department of Biotechnology, school of science and Technology, Nottingham Trent University, Nottingham, UK
  • Mohammad Reza Mohammadi Department of Bacteriology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
  • Mohammad Ali Zonobian Department of Food Microbiology, School of Allied Medical Sciences, Iran University of Medical Sciences, Tehran, Iran
  • Masomeh Nazari Department of Medical Genetics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
  • Fardin Fathi Cellular and Molecular Research Center, Kurdistan University of Medical Sciences, 6617713446 Sanandaj, Kurdistan, Iran
  • Saba Dadpour Nanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
  • Paria Habibi Islamic Azad University, Science and Research, Tehran, Iran
  • Soheila Kashanian Faculty of Chemistry, Razi University, Kermanshah 6714414971, Iran; Nanobiotechnology Department, Faculty of Innovative Science and Technology, Razi University, Kermanshah 6714414971, Iran
  • Morahem Ashengroph Department of Biological Science, Faculty of Science, University of Kurdistan, Sanandaj, Kurdistan, Iran; Research Center for Nanotechnology, University of Kurdistan, Sanandaj, Kurdistan 66177-15175, Iran
  • Hadi Mohammadzade Student Research Committee, Semnan University of Medical Sciences, Semnan, Iran
  • Yousef Azarakhsh Department of Basic Science & Pathobiology, Faculty of Veterinary Medicine, Razi University, Kermanshah, Iran
  • Sepehr Kahrizi Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
  • Mehran Alavi Nanobiotechnology Department, Faculty of innovative Science and Technology, Razi University, Kermanshah, Iran
  • Zhenchao Xu Department of Gastrointestinal Surgery, The Affiliated Taian City Centeral Hospital of Qingdao University,Tai’an, Shandong Province, China


Molecularly imprinted polymer, Cancer diagnosis, Antibiotic detection, Biomedical applications


Molecularly imprinted polymers (MIPs) are pivotal in medicine, mimicking biological receptors with enhanced specificity and affinity. Comprising templates, functional monomers, and cross-linkers, MIPs form stable three-dimensional polymer networks. Synthetic templates like glycan and aptamers improve efficiency, guiding the molecular imprinting process. Cross-linking determines MIPs' morphology and mechanical stability, with printable hydrogels offering biocompatibility and customizable properties, mimicking native extracellular matrix (ECM) microenvironments. Their versatility finds applications in tissue engineering, soft robotics, regenerative medicine, and wastewater treatment. In cancer research, MIPs excel in both detection and therapy. MIP-based detection systems exhibit superior sensitivity and selectivity for cancer biomarkers. They target nucleic acids, proteins, and exosomes, providing stability, sensitivity, and adaptability. In therapy, MIPs offer solutions to challenges like multidrug resistance, excelling in drug delivery, photodynamic therapy, photothermal therapy, and biological activity regulation. In microbiology, MIPs serve as adsorbents in solid-phase extraction (SPE), efficiently separating and enriching antibiotics during sample preparation. They contribute to bacterial identification, selectively capturing specific strains or species. MIPs aid in detecting antibiotic residues using fluorescent nanostructures and developing sensors for sulfadiazine detection in food samples. In summary, MIPs play a pivotal role in advancing medical technologies with enhanced sensitivity, selectivity, and versatility. Applications range from biomarker detection to innovative cancer therapies, making MIPs indispensable for the accurate determination and monitoring of diverse biological and environmental samples.